Smart motorway works on the M4 will see the road closed for a full weekend.
The motorway will be shut between the Langley and the M25 interchange, from late on Friday, February 11 to the early hours of Monday, February 14.
Drivers travelling to London and Heathrow Airport will be among those affected by the latest closure, which is part of the National Highways project to make the road four running lanes.
Read more: Reading's worst potholes to be repaired as roadworks planned for 281 roads
There will also be a slip road closure overnight on Friday at junction 10.
The roll out of the controversial smart motorways programme was halted earlier this year while more data is gathered, but this hasn't stopped work from continuing between junction 3 for Hayes and junction 12 at Theale.
The eastbound exit slip road of the M4 will be closed overnight on Friday, February 11.
The slip road at junction 10 for Wokingham and Bracknell is due to close at 8pm and is expected to reopen by 6am on Saturday, February 12.
The closure is part of the ongoing smart motorway works.
Drivers wanting to leave the motorway at junction 10, should exit at junction 11 for Reading and take Lower Earley Way instead, or they can leave at junction 8/9 for Maidenhead and use the A4 towards Reading.
All traffic will be diverted off the M4 as it closes for the entire weekend.
The road will be closed in both directions between junction 5 for Langley and junction 4b for the M25, from 11pm on Friday, February 11 until 5.30am on Monday, February 14.
The M25 link roads from junction 15 to junction 4b will also be closed throughout the weekend. Drivers will be diverted off the motorway and should follow the signed diversion.
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