Tea consumption is associated with hyperuricemia | IJGM


Hyperuricemia is an important risk factor for gout and accounts for a large proportion of inflammatory arthritis cases in men.1Chronic hyperuricemia leads to long-term deposition of monosodium urate crystals that may damage the structure of the joints and affect the quality of life.2Moreover, hyperuricemia is an independent determinant of cardiovascular disease,3–5chronic kidney disease,3,6diabetes,7,8and all-cause mortality.3,9Although the prevalence of hyperuricemia varies depending on geographic region, ethnicity, and the research methods used, the findings of most studies indicate an increase in the number of people with hyperuricemia worldwide.10According to the 2007–2008 US National Health and Nutrition Examination Survey, approximately 21.4% of adults in the US had hyperuricemia.11A meta-analysis that summarized the results of studies performed in China from 2000 to 2014 showed that 13.3% of the Chinese population suffered from hyperuricemia.12Furthermore, another study of an eastern Chinese population reported that 20.7% of men and 5.6% of women were affected by hyperuricemia.13The rising prevalence of hyperuricemia worldwide is now considered an emerging public health problem.14Therefore, identifying modifiable risk factors for hyperuricemia is crucial to address this public health concern.

Various factors affect the serum uric acid (SUA) concentration, including tea consumption (green, black, or other types) and other dietary factors.15Studies have shown that low-fat dairy products (eg, milk and yogurt), vegetables, whole grains, nuts and legumes, fruits that are low in sugar, coffee, and vitamin C supplements can decrease SUA levels, while consumption of red meat, fructose-containing beverages, and alcohol can increase the risk of hyperuricemia.16

After water, tea is one of the most popular beverages worldwide, especially in Asia.17People living in Guangdong province are fond of drinking tea. Findings on the association between tea consumption and SUA levels have been inconsistent in previous studies. For example, some studies have shown that tea consumption can reduce SUA levels in humans15,18and animals,19whereas others have demonstrated that tea20or its extracts18are associated with a higher SUA level. However, the relationship between tea intake and hyperuricemia remains unclear.20A non-significant association between tea consumption and hyperuricemia has also been reported.21–23Therefore, the effect of tea consumption on hyperuricemia requires further clarification.

This study aimed to assess the association between hyperuricemia and frequency of tea consumption in the working population of Guangdong, China, after adjustment for sociodemographic factors, anthropometric and biochemical indices, and dietary factors. We also estimated the risk of hyperuricemia according to sex.

Materials and Methods

This cross-sectional study analyzed data from the health examinee dataset held at Nanfang Hospital (Southern Medical University, Guangzhou, China), which contains information on working individuals who visit Nanfang Hospital for health checkups. We extracted the data of individuals aged ≥18 years who visited the hospital between 2015 and 2020. The selection process is shown in Figure 1. In brief, participants with missing data on height and weight (n=170), education level (n=72), smoke (n=50), drink (n=84), biochemical parameters (n=130), and other characteristics (n=137) were excluded. The final sample included data for 3149 individuals with hyperuricemia and 4495 without hyperuricemia. The frequency of tea consumption (green, black, or other types) was investigated.

Figure 1 The selection of study participants.

We collected the resultant data from several anthropometric measurements (ie, weight, height, and blood pressure), biochemical tests (ie, SUA, serum creatinine [SCr], cholesterol [CHOL], triglyceride [TG], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and fasting blood glucose [FBG]), and a questionnaire. The questionnaire was obtained from Guangdong Provincial Key Area R&D Program (2019B020227004) for large-scale cohort study and clinical sample bank and database construction. All investigations were performed on the same day.

Anthropometric measurements were performed by trained examiners. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters. Blood pressure was measured using a standard mercury sphygmomanometer. Fasting blood samples were collected between 7:00 AM and 9:30 AM after fasting overnight. All participants provided on-site blood samples at the time of their physical examination. Blood samples were centrifuged and separated for clinical laboratory testing; serum lipid profiles along with SUA, SCr, and FBG levels were examined by standard laboratory methods in the same laboratory. Although there is no consensus definition of hyperuricemia based on the SUA level, a diagnosis of hyperuricemia was made if the SUA level was >420 µmol/L in men and >360 µmol/L in women according to previous reports.24–26

Presence of a history of hypertension was determined. Smoking status and alcohol consumption were classified as “yes” and “no”. Education level was classified as senior high school or lower, college level, and bachelor’s degree or higher. In terms of dietary factors, we investigated whether the participants had a salty diet and the frequency of overeating. Midnight snacking was divided into “yes” and “no” categories. The frequencies of barbecue or fried food intake, corned or smoked food consumption, and dining out were categorized as never, 1–2 times per month, and 1–2 times per week or more. According to the distribution of the categories in the study sample, we classified the frequency of tea intake as never, once a month through twice a week, and ≥3 times a week.

The normality of continuous variables was assessed using the Kolmogorov–Smirnov test. Descriptive statistics were calculated for all continuous variables (reported as the mean and standard deviation) and categorical variables (reported as the number and percentage). The characteristics of individuals with and without hyperuricemia were compared using the t-test or the non-parametric Mann–Whitney U-test for continuous variables and the Pearson’s chi-square test for categorical variables. The relationships between hyperuricemia and participant characteristics (sex, age, education level, smoking history, alcohol consumption, hypertension, BMI, tea intake, and other dietary factors) were first examined in a univariate logistic regression model. Variables with a P-value <0.05 in the univariate analysis were entered into a multivariate logical regression model to identify independent risk factors for hyperuricemia. Odds ratios (ORs) for effect estimation were calculated with the 95% confidence intervals (CIs).

Tea consumption is associated with hyperuricemia | IJGM

Three models were constructed to investigate the effect of tea intake on the risk of hyperuricemia. Potential risk factors were selected for these multivariable models based on the univariate regression analysis (p<0.05) and published literature. There have been reports indicating an association between the risk of hyperuricemia and SCr, CHOL, TG, LDL-C, HDL-C, and FBG levels.13,27–33The first model was adjusted for age, sex, and BMI. The second model was further adjusted for SCr (μmol/L), CHOL (mmol/L), TG (mmol/L), LDL-C (mmol/L), HDL-C (mmol/L), FBG (mmol/L), and hypertension. The third model was adjusted for model 2 plus educational level, smoking status, alcohol consumption, salty diet, midnight snacking, overeating, frequency of dining out, frequency of barbecue or fried food intake, and frequency of corned or smoked food intake.

Two-tailed statistical analyses were performed using IBM SPSS Statistics for Windows version 26.0 software (IBM Corp., Armonk, NY, USA). A P-value <0.05 was considered statistically significant.


The characteristics of the 7644 study participants are presented in Table 1 and stratified based on the presence of hyperuricemia. In total, 3149 participants had hyperuricemia, which was significantly more common in men (77.7%) than in women (22.3%). SUA levels were normal in 4495 participants. The mean (standard deviation) age was 34.7 (8.9) years. The participants with hyperuricemia were significantly older and had a significantly higher BMI than those without hyperuricemia. There were between-group differences in smoking status, alcohol consumption, and educational level (all P<0.001). Hypertension was more common in the hyperuricemia group than in the control group (4.5% vs 2.2%, P<0.001). Mean values for most of the anthropometric and biochemical indices were within the normal range; however, the average TG level was slightly above the normal range in the hyperuricemia group. Moreover, the mean SCr, CHOL, TG, and LDL-C levels were higher in the hyperuricemia group than those in the control group; there was an inverse correlation for HDL-C. No significant difference was observed in the FBG level between the groups. Between-group differences in dietary factors, including salty diet, midnight snacking, and overeating, along with the frequencies of dining out, intake of barbecue or fried food, and intake of corned or smoked food, were statistically significant (all P<0.05). There was also a difference in the frequency of tea intake between the two groups (P<0.001).

Table 1 Characteristics and Comparison Between Subjects with Hyperuricemia and Without Hyperuricemia

Univariate logistic regression analysis showed a significant association between hyperuricemia and tea intake (OR 1.744, 95% CI 1.481–2.053 for once a month through twice a week vs never, P<0.001; OR 2.444, 95% CI 2.070–2.886 for ≥3 times a week vs never, P<0.001). Other categorical characteristics were also associated with hyperuricemia (Table 2).

Table 2 Comparison of Some Characteristics with Hyperuricemia Using Univariate Logistic Regression Models

After selecting potential risk factors based on the univariate logistic models, multivariable logistic regression was conducted based on the frequency of tea intake in the three models. The association between tea intake and increased risk of hyperuricemia remained significant in all models. In model 3, the adjusted OR for hyperuricemia was 1.30 (95% CI 1.08–1.56, P=0.006) in participants who consumed tea once a month through twice a week and 1.35 (95% CI 1.11–1.64, P=0.003) in those who consumed tea ≥3 times a week when compared with the never reference group. The results showed that tea consumption was an independent risk factor for hyperuricemia (Table 3).

Table 3 Crude and Adjusted Odds Ratios (95% Confidence Interval) for Hyperuricemia According to Tea Consumption

The prevalence of hyperuricemia was higher in male participants compared to that in the female participants. Therefore, we performed sex-based subgroup analyses. This relationship remained significant between hyperuricemia and tea consumption in the three models among the male participants. However, there was no significant relationship between hyperuricemia and tea intake among the female participants (Figures 2 and 3).

Figure 2 Crude and adjusted odds ratios for hyperuricemia according to tea consumption in men.

Figure 3 Crude and adjusted odds ratios for hyperuricemia according to tea consumption in women.


In this cross-sectional study, we analyzed the association between hyperuricemia and tea intake using data from the health examinee database at Nanfang Hospital and found that higher tea consumption was associated with a greater risk of hyperuricemia. This association remained after adjustment for potential confounders, including age, sex, BMI, educational level, smoking status, alcohol consumption, intake of barbecue or fried food, intake of corned or smoked food, salty diet, overeating, dining out, midnight snacking, and biochemical indices (SCr, CHOL, TG, LDL-C, HDL-C and FBG, identified by univariate regression analysis and in the published literature13,27–33). These adjustments did not change the results, suggesting that tea consumption is an independent risk factor for hyperuricemia.

The relationship between tea intake and hyperuricemia has been investigated previously. Some studies have shown that tea consumption may be negatively associated with hyperuricemia.19,34Conversely, a meta-analysis demonstrated that tea intake did not seem to be associated with hyperuricemia.21Furthermore, the results of two population-based studies in Asia indicated that the association between hyperuricemia and tea intake needs validation in future studies.20,23Contrary to previous studies, our findings indicated a positive association between hyperuricemia and tea intake.

The mechanism of the effect of tea consumption on hyperuricemia has not yet been determined. Beneficial health effects have been attributed to the polyphenols in tea, which have been mainly discussed in the experimental context.17It has been reported that catechins and theaflavins can effectively inhibit xanthine oxidase, reducing the production of uric acid.19,35Nevertheless, there exists contradiction between the findings of experimental and epidemiological studies, and a subgroup analysis for green tea in a meta-analysis displayed that its consumption was positively associated with the SUA level,21which is in agreement with our findings. There are three possible explanations for the inconsistency between the previous experimental and epidemiological findings. First, catechins reversely regulate the expression of organic anion transporter 1,36a secreting protein for uric acid excretion, which could account for the increase in SUA.37Second, the positive effects of tea extracts or polyphenols on the SUA level might be better clarified in animal models than in humans.21Moreover, some overlooked substances in tea might increase the SUA level, and overconsumption of tea could have harmful effects. Finally, the health status of the study participants could have influenced their SUA levels. Indeed, previous studies have demonstrated associations between hyperuricemia and cardiovascular disease, renal disease, diabetes, hypertension, and other diseases.3–8

Previous research has shown that the prevalence of hyperuricemia is similar between men and women in the population aged over 50 years.38The majority of the participants in our study were under 48 years of age, and it is possible that sex-related differences in hyperuricemia are more pronounced in this age group. We found a significant association between tea consumption and the risk of hyperuricemia in men in all three of our models but not in women. Many factors potentially contributed to the difference. One reason for this finding may be that women tend to have a healthier lifestyle than men; for example, smoking and alcohol consumption rates were lower in women in the present study. Secondly, a recent report showed a high prevalence of hyperuricemia among hypertensive patients,39and hypertension was more common in men in our study. Furthermore, gender differences in gene function may lead to different SUA metabolism levels.40Additionally, biological factors, including estrogen, may protect against the development of hyperuricemia in women.41

This study has several strengths. First, contrary to previous studies, which suggested that tea intake was not associated with hyperuricemia or that tea protected against hyperuricemia, we found tea intake to be a significant risk factor for hyperuricemia. Furthermore, our study included three models that accounted for a wide range of covariates, including sociodemographic, anthropometric, biochemical, and dietary factors. The study also has several potential limitations. First, the association between tea intake and hyperuricemia was investigated in a cross-sectional and single-centric manner despite the large sample size, which limited temporality and universality assessment. We anticipate involving multiple institutions in the future and following up to conduct longitudinal analyses for further research. Second, the information on tea consumption was self-reported and collected by questionnaires that used frequency categories rather than exact values, which may have introduced a degree of recall bias and misclassifications of exposure. Besides, we did not elaborate on the medical conditions about drugs affecting SUA levels in the questionnaire that were relevant to this study. Therefore, we aim to include this information for further analysis in the future follow-up study. Finally, although we controlled for several potential risk factors, we cannot exclude the possibility of unmeasured or residual confounding factors.


This study demonstrated a positive association between the frequency of tea consumption and the risk of hyperuricemia in the Chinese working population in Guangdong province. Subgroup analysis revealed that this effect was more pronounced in men than in women. There is a need for well-designed cohort studies with precise measurements of tea consumption to confirm our findings. Further studies are also required to elucidate the underlying mechanisms.